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formation is endocrine end-organ failure, as occurs, for example, with ovarian atrophy that induces a basophilic adenoma Only a small proportion (6 to 8 percent) enlarge the sella, ie, most are microadenomas as discussed below On the basis of conventional hematoxylin-eosin staining methods, cells of the normal pituitary gland were for many years classi ed as chromophobe, acidophil, and basophil, these types being present in a ratio of 5:4:1 Adenomas of the pituitary are most often composed of chromophobe cells (4 to 20 times as common as acidophilcell adenomas); the incidence of basophil-cell adenomas is uncertain Histologic study is now based on immunoperoxidase staining techniques that de ne the nature of the hormones within the pituitary cells both of the normal gland and of pituitary adenomas These methods have shown that either a chromophobe or an acidophil cell may produce prolactin, growth hormone (GH), and thyroid-stimulating hormone (TSH), whereas the basophil cells produce adrenocorticotropic hormone (ACTH), beta-lipotropin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) The development of sensitive (radioimmunoassay) methods for the measurement of pituitary hormones in the serum has made possible the detection of adenomas at an early stage of their development and the designation of several types of pituitary adenomas on the basis of the endocrine disturbance Hormonal tests for the detection of pituitary adenomas, preferably carried out in an endocrine clinic, are listed in Table 31-3 Between 60 and 70 percent of tumors, in both men and women, are prolactin-secreting About 10 to 15 percent secrete growth hormone, and a smaller number secrete ACTH Tumors that secrete gonadotropins and TSH are quite rare These tumors may be monohormonal or plurihormonal and approximately one-third are composed of nonfunctional (null) cells Pituitary tumors usually arise as discrete nodules in the anterior part of the gland (adenohypophysis) They are reddish gray, soft (almost gelatinous), and often partly cystic, with a rim of calcium in some instances The adenomatous cells are arranged diffusely or in various patterns, with little stroma and few blood vessels; less frequently the architecture is sinusoidal or papillary in type Variability of nuclear structure, hyperchromatism, cellular pleomorphism, and mitotic gures are interpreted as signs of maTable 31-3 Hormonal tests for detection of pituitary adenomas.

in and A table lookup is a common task that is frequentlyencountered engineering science performing repeated interpolations fiorrr a table of computer applicationsIt is useful tbr variablesFor example,suppose that you would like to set up independent and dependent teman M-file that would use linear interpolationto determineair density at a particular peraturebasedon the datafrom Table 1-51 One way to do this would be to passtlreM-file to the temperature which you want the interpolation be performedalong with thetwoadat joining values more generalapproach would be to passin vectorscontainingall thedata A and have the M-file detenninethe bracketThis is called a table lookup variThus, the M-file would perform two tasksFirst, it would search independent the able vector to find the intervirl containingthe unknorvnThen it would performthelineat in interpolation usingone of the techniques described this chapter in Chap15 or a For ordereddata, there are two simple ways to find the interval The first is called value sequentialsearchAs the name impliesthis methodinvolves comparingthe desired with each elementof the vector in seqnence until the interval is locatedFor datain asbeing cendingorder,this can be doneby testingwhetherthe unknownis lessthanthe value one lf assessed so, we know that the unknown falls betweenthis value and the previous is Here a that we examinedlf not, we move to the next value and repeatthe comparison this simpleM-file that accomplishes objective:

If you re familiar with JavaScript but know nothing about either Visual Basic or C#, you might want to try using either J# or JScriptNET Both have the feel of JavaScript but are different from each other However, unless you have a good reason to do so, such as working in an environment where J# or JScriptNET is used, C# is recommended First, you will find many similarities between these languages and C#, so it s not a big leap Also, as with VBNET, if you learn using C# with ASPNET, you ll be getting it in light doses

Serum prolactin level, chlorpromazine- or TRH-provocative tests, L-dopa suppression Serum GH level, glucagon, L-dopa, glucoseGH suppression, somatomicid C Serum cortisol, urinary steroids, metyrapone test, dexamethasone suppression Serum FSH, LH, estradiol, testosterone, GnRH stimulation TSH, T4, TRH Urine and serum osmolality after water restriction for de ciency of hormone; without water restriction for excess of hormone

functior-i n if xx error yi = Tablelook(;<, y, rr)

Key: FSH, follicle-stimulating hormone; LH, luteinizing hormone; GnRH, gonadotropin-releasing hormone; TRH, thyrotropin-releasing hormone; T4, thyroxine; TSH, thyroid-stimulating hormone; GH, growth hormone

Using tools to aid in creating ASPNET applications Understanding Visual Studio 2008 Installing Visual Studio 2008 Creating ASPNET 35 applications Testing applications Using other web development tools Entering code in text editors

cngrn'X); < r(1) xx > x(n) (' Inter1;,olation outside search range' )

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t some level in coding, just about everything can be done with a simple text editor Using a text editor to write code gives you an enormous amount of flexibility and a deeper understanding of what your program is doing In working with ASPNET 35, the same is true, but creating ASPNET applications with Notepad or TextEdit will put the learning curve pretty high As you saw in 1, an ASPNET program is actually a combination of ASPNET coding and C# So, keeping track of things with a text editor is a little tricky In this chapter you ll be learning about a wonderfully powerful tool that will not only aid in your learning all about building applications, but also will help your learning about the code in the files you will be building