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course of the illness By comparison, there are about 200,000 new cases of breast cancer yearly Among causes of death from intracranial disease, tumor is exceeded in frequency only by stroke By contrast, in children, primary tumors of the brain constitute the most common solid tumor and represent 22 percent of all childhood neoplasms, second in frequency only to leukemia Viewed from another perspective, in the United States, the yearly incidence of all tumors that involve the brain is 46 per 100,000, and of primary brain tumors, 15 per 100,000 It is dif cult to obtain accurate statistics as to the types of intracranial tumors, for most of them have been obtained from university hospitals with specialized neurosurgical centers, which attract the more easily diagnosed and treatable forms For example, from the gures of Posner and Chernik, one can infer that secondary tumors of the brain greatly outnumber primary ones; yet in the large series reported in the past (those of Cushing, Olivecrona, Zulch, and Zimmerman), only 4 to 8 percent were of this type In the autopsy statistics of municipal hospitals, where one would expect a more natural selection of cases, the gures for metastatic tumors vary widely, from 20 to 42 percent (Russell and Rubinstein) Even these estimates probably err on the low side, since the brain is frequently not examined in cancer patients, and many of the patients with more benign tumors may have found their way to specialized neurosurgical services With these quali cations, the gures in Table 31-1 might be taken as representative In broad terms, most primary brain tumors are of glial-cell origin ie, gliomas a category that includes astrocytomas (which occur in several grades of malignancy), oligodendrogliomas, ependymomas (which may have characteristics of both glia and of epithelium), and a number of rarer types Other tumors arise from ectodermal structures related to the brain (meningioma); an increasingly important group arises from lymphocytes or their progenitor histiocytes, ie, reticulum cells (CNS lymphoma); a varied constellation is derived from precursor neuronal elements (neuroblastoma, medulloblastoma), germ cells (germinoma, craniopharyngioma, teratoma, etc), or endocrine elements (pituitary adenoma) A more recent and detailed tabulation is given in Table 31-2, compiled by the Central Brain Tumor Registry Notable in all series, and emphasized in the latter table, is the higher frequency of certain tumors during childhood The main change since the rst edition of this book (1977) is the increase in incidence of primary CNS lymphomas When Table 31-1 was rst composed, the incidence of this tumor, formerly called reticulum-cell sarcoma, was almost negligible In the last 25 years, the number in our hospitals has more than tripled; in specialized centers such as the Memorial Sloan-Kettering Cancer Center, the increase in incidence has been even more dramatic (DeAngelis) In most institutions, one in ve or six primary brain tumors is now of this type For the most part, this increase is attributable to the rise in number of immunosuppressed individuals, particularly of those with AIDS; but the incidence of this tumor.

The group name The password for gaining membership to the group This is often ignored The password is encrypted using the same technique as the login password information See Password Encryption for more details The numerical group ID A space-separated list of the user names (not IDs) that are members of this group

Copyright 2005, 2001, 1997, 1993, 1989, 1985, 1981, 1977, by The McGraw-Hill Companies, Inc Click here for terms of use

3 525

Table 11-3

Table 31-1 Types of intracranial tumor in the combined series of Zulch, Cushing, and Olivecrona, expressed in percentage of total (approximately 15,000 cases)

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All passwords on Unix are encrypted using a standard system function called crypt() This uses an algorithm that is one-way the idea being that the time taken to decode the encrypted text would take more processing power than is available in even the fastest computer currently available This complicates matters if you want to compare a password against the recorded password The operation for password checking is to encrypt the user-supplied password and then compare the encrypted versions with each other This negates the need to even attempt decrypting the password The Perl encryption function is also crypt, and it follows the same rules There are two arguments the string you want to encrypt and a salt value The salt value is an arbitrary string used to select one of 256 different combinations available for the encryption algorithm on the specified string Although the rules say the size of the salt string should be a maximum of two characters, there is no need to reduce the string used, and the effects of the salt value are negligible In most situations you can use any two-character (or more) string For example, to compare a supplied password with the system version:

Gliomas Glioblastoma multiforme Astrocytoma Ependymoma Medulloblastoma Oligodendroglioma Meningioma Pituitary adenoma Neurinoma (schwannoma) Metastatic carcinoma Craniopharyngioma, dermoid, epidermoid, teratoma Angiomas Sarcomas Unclassi ed (mostly gliomas) Miscellaneous (pinealoma, chordoma, granuloma, lymphoma)b Total

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$realpass = (getpwuid($<))[1]; die "Invalid Password" unless(crypt($pass,$realpass) eq $realpass);

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MATLAB and its Toolboxes havea rich collection built-infunctions of You can useonline help to find out nroreaboutthem For exampleif you want to learnaboutthe 1og function, type rn

growth potential (degree of nuclear atypia, cellularity, mitoses, and vascular changes) and prognosis The glioblastomas, which are largely de ned by the added features of necrosis and anaplasia of nonneural elements such as vascular proliferation, are set apart from anaplastic astrocytomas on the basis not only of their histology but also by a later age of onset than astrocytoma and a more rapid course Tumors formerly classi ed as grade I astrocytomas are rare and dif cult to distinguish from hamartomas; therefore they are currently omitted from most classi cations In the WHO system, grade I is reserved for the relatively benign pilocytic astrocytomas (well-differentiated tumors mostly of children and young adults) Similarly, the pleomorphic xanthoastrocytomas (with lipid- lled cells) and the subependymal giant-cell astrocytomas (usually associated with tuberous sclerosis) have been set apart because of their different growth patterns, pathologic features, and prognosis The ependymomas are subdivided into cellular, myxopapillary, clear-cell, and mixed types; the anaplastic ependymoma and the subependymoma are given separate status The pathologic criteria of malignant astrocytoma do not apply to oligodendroglioma,

The fact that the password cannot be cracked means the encryption system is useless for encrypting documents For that process, it is easier to use one of the many encryption systems available via CPAN

In children, the proportions differ: astrocytoma, 48 percent; medulloblastoma, 44 percent; ependymoma, 8 percent Seventy percent of gliomas in children are infratentorial; in adults, 70 percent are supratentorial Craniophrayngioma also occurs mainly in younger age groups The incidence of lymphoma was negligible when these series were collected, but it has increased markedly since then (see text)

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